Scientific Publications
Scientific Peer-Reviewed Manuscripts and Scientific Abstracts, Books, and Reviews
- (1986 through April 24, 2008)
* indicates external, non-sponsored study.
Disclaimer: Please note that these articles were not prepared by OPK Biotech and the listing is not intended to imply OPK Biotech's endorsement of the analysis or conclusions in any of the articles. They are included for the convenience of individuals in reading more about scientific studies related to oxygen therapeutics. Where available we have included links to the article abstracts on PubMed that will open in a new window. When visiting linked abstracts, you will be leaving the OPK Biotech website. OPK Biotech does not review or control the content at PubMed.
Human Clinical
Agrawal YP, Freedman M, Szczepiorkowski ZM. Long-term transfusion of polymerized bovine hemoglobin in a Jehovah's Witness following chemotherapy for myeloid leukemia: a case report. Transfusion. 2005;45(11):1735-1738.
Gonzalez P, Hackney AC, Jones S, Strayhorn D, Hoffman EB, Hughes G, Jacobs EE, Orringer EP. A phase I/II study of polymerized bovine hemoglobin in adult patients with sickle cell disease not in crisis at the time of study. J Investig Med. 1997;45(5):258-264.
Hughes GS, Antal EJ, Locker PK, Francome SF, Adams WJ, Jacobs EE. Physiology and pharmacokinetics of a novel hemoglobin-based oxygen carrier in humans. Crit Care Med. 1996;24(5):756-764.
Hughes GS, Francome SF, Antal EJ, Adams WJ, Locker PK, Yancey EP, Jacobs EE. Effects of a novel hemoglobin-based oxygen carrier on percent oxygen saturation as determined with arterial blood gas analysis and pulse oximetry. Ann Emerg Med. 1996;27(2):1-6.
Hughes GS, Francome SF, Antal EJ, Adams WJ, Locker PK, Yancey EP, Jacobs EE. Hematologic effects of a novel hemoglobin-based oxygen carrier in normal male and female subjects. J Lab Clin Med. 1995;126(5):444-451.
Hughes GS, Yancey EP, Albrecht R, Locker PK, Francome SF, Orringer EP, Antal EJ, Jacobs EE. Hemoglobin-based oxygen carrier preserves submaximal exercise capacity in humans. Clin Pharmacol Ther. 1995;58(4):434-443.
Hughes G, Jacobs E, Antal E, Yancey B, Francom S, Locker P, Riggin J. Pharmacokinetics of a novel hemoglobin-based oxygen carrier in humans. Crit Care Med. 1995;23(1):A257. Oral Presentations: Pharmacology. Abstract.
Hughes GS, Jacobs EE, Francome SF, Locker PK, Riggin JL. Ferrobiology of a novel hemoglobin-based oxygen carrier in normal male and female subjects. Blood. 1994;84(10):668a. Abstract.
Jacobs EE, Gawryl MS. Use of Hemoglobin Based Oxygen Carrier-201 when blood is not available or not acceptable. Transfusion. 2000;40(S152):41S.
Jahr JS, Stewart LM, Mackenzie C, Bourke D, Williams JP. Pivotal phase III study: safety of polymerized bovine hemoglobin (HBOC-201, Hemopure®) as compared to RBC in patients undergoing orthopedic surgery. Anesthesiology. 2002;96:A243. Abstract.
Jahr JS, Liu H, Gull A, Maollempour M, Lim J, Gosselin R. Does HBOC-201 (Hemopure®) affect platelet function in orthopedic surgery: a single site analysis. Anesth Analg. 2008;106:S-1-S-244. Abstract.
Kasper SM, Grune F, Walter M, Amr N, Erasmi H, Buzello W. The effects of increased doses of bovine hemoglobin on hemodynamics and oxygen transport in patients undergoing preoperative hemodilution for elective abdominal aortic surgery. Anesth Analg. 1998;87:284-291.
Kasper SM, Walter M, Grune F, Bischoff A, Erasmi H, Buzello W. Effects of a hemoglobin-based oxygen carrier (HBOC-201) on hemodynamics and oxygen transport in patients undergoing preoperative hemodilution for elective abdominal aortic surgery. Anesth Analg. 1996;83:921-927.
LaMuraglia GM, O'Hara PJ, Baker WH, Naslund TC, Norris EJ, Li J, Vandermeersch E. The reduction of the allogenic transfusion requirement in aortic surgery with hemoglobin-based solution. J Vasc Surg. 2000;31(2):299-308.
Levien LJ. South Africa: clinical experience with Hemopure. ISBT Science Series.2006;1:167-173.
Levien LJ. Bovine hemoglobin (Hemopure): Clinical Use in South Africa. Accepted for oral presentation at the Xth International Symposium on Blood Substitutes, Brown University, Providence, RI, June 14, 2005, abstract.
Levien LJ. Clinical Use of Hemopure (HBOC 201) in South Africa. Presented at the Annual Meeting of the Vascular Society of Southern Africa. Stellenbosch, South Africa. October 2003 Abstract.
Levien LJ. Clinical Use of Hemopure (HBOC 201) in South Africa. Presented at the Controversies and Problems in Surgery IX Symposium. University of Pretoria, South Africa. October 2003 Abstract.
Levy JH, Goodnough LT, Greilich PE, Parr G, Stewart RW, Gratz I, Wahr J, Williams J, Comunale ME, Doblar D, Silvay G, Cohen M, Jahr JS, Vlahakes GJ. Polymerized bovine hemoglobin solution as a replacement for allogeneic red blood cell transfusion after cardiac surgery: Results of a randomized, double-blind trial. J Thorac Cardiovasc Surg. 2002;124(1):35-42.
Levy JH, Goodnough LT, Greilich P, Parr G, Stewart RW, Gratz I, Wahr J, Williams J, Comunale M, Vlahakes G. A room-temperature stable hemoglobin (HBOC-201) eliminates allogeneic red blood cell (RBC) transfusion in post-operative cardiac surgery patients. Circulation. 1998;17(Suppl 1):132. Abstract.
Monk TG, Goodnough LT, Peruzzi WT, Byers PM, Jacobs EE, Silverman MH. A dose-escalation study to evaluate the kinetics and hemodynamic effects of hemoglobin-based oxygen carrier-201. Anesthesiology.1997;87(3A):A214. Abstract.
Monk TG, Goodnough L, Hughes G, Jacobs EE. Evaluation of the safety and tolerance of hemoglobin-based oxygen carrier-201. Anesthesiology. 1995;83(3A):A285. Abstract.
Mullon J, Giacoppe G, Clagett C, McCune D, Dillard T. Transfusions of polymerized bovine hemoglobin in a patient with severe autoimmune hemolytic anemia. New Engl J Med. 2000;342(22):1638-1643.
Niquille M, Touzet M, Leblanc I, Baron JF. Reversal of intraoperative myocardial ischemia with a hemoglobin-based oxygen carrier. Anesthesiology. 2000;92(3):882-885.
Orringer EP, Gonzalez PM, Hackney AC, Jones SK, Hoffman EB, Jacobs EE, Hughes GS. A phase I study of polymerized bovine hemoglobin (PBH) in adult patients with sickle cell disease not in crisis at the time of study. In: Beuzard Y, Lubin B, Rosa J, eds. Sickle Cell Disease and Thalassaemias: New Trends in Therapy: Proceedings of the International Conference "New trends in therapy for hemoglobinopathies and thalassaemias." Paris, France: Colloque Inserm; 1995;234:301-302.
Pearce LB, Pitman AN, Connolly M. Risk of adverse outcome due to acute anemia in the orthopedic surgical setting. Clinical Pharmacology & Therapeutics. 2008;83(Suppl 1):S39;OII-B-4. Abstract.
Pearce LB, Pitman AN, Greenburg AG. Breaking the rules: misinterpretation of dose-response relationships in clinical trials. Clinical Pharmacology & Therapeutics. 2008;83(Suppl 1):S87;PIII-50. Abstract.
Pearce LB, Pitman A, Greenburg AG, Freilich DA, Kaplan L. Application of a unique scoring system for numerical determination of a benefit risk ratio in clinical trials. Clinical Pharmacology & Therapeutics. 2008;83(Suppl 1):S87-88;PIII-52. Abstract.
Pearce LB, Gawryl MS, Rentko VT, Moon-Massat PF, Rausch CW. HBOC-201 [Hemoglobin Glutamer-250 (bovine), Hemopure]: clinical studies. In: .Winslow R. (ed) Blood Substitutes. London, England: Elsevier Inc;:2006:437-450.
Pitman AN, Pearce LB. A flexible outcome scoring system for clinical trials. Clinical Pharmacology & Therapeutics. 2008;83(Suppl 1):S87PIII-51. Abstract.
Slagboom T, Laarman GJ, de Winter RJ, Schuler G, Thiele H, Heyndrickx GR, Regar E, Serruys PW. Hemoglobin based oxygen therapeutics in (elective) percutaneous (coronary) revascularization -- Safety trial. Accepted for oral presentation at the Xth International Symposium on Blood Substitutes, Brown University, Providence, RI, June 14, 2005, abstract.
Sprung J, Kindscher JD, Wahr JA, Levy JH, Monk TG, Moritz MW, O'Hara PJ. The use of bovine hemoglobin glutamer-250 (Hemopure®) in surgical patients: results of a multicenter, randomized, single-blinded trial. Anesth Analg. 2002;94(4):799-808.
Sprung J, Popp H, O'Hara PJ, Woletz J. The successful use of hemoglobin-based oxygen carrier as a primary blood substitute during abdominal aneurysm repair with large blood loss. Anesth Analg. 2001;92;1413-1415.
Sprung J, Kindscher JD, Wahr JA, Levy JH, Monk TG. Plasma hemoglobin and methemoglobin concentrations after infusion of bovine hemoglobin-based oxygen carrier (HBOC) in surgical patients. American Society of Anesthesiologists. 2001;95:A394. Abstract.
Standl T, Burmeister MA, Horn EP, Wilhelm S, Knoefel WT, Schulte am Esch J. Bovine haemoglobin-based oxygen carrier for patients undergoing haemodilution before liver resection. Br J Anaesth. 1998;80(2):189-194.
Standl T, Wilhelm S, Horn P, Schumacher J, Schulte am Esch J. Preliminary experience with ultra-purified bovine hemoglobin in patients undergoing preoperative hemodilution prior to liver resection. Anesthesiology. 1996;85(3A):A63. Abstract.
Wahr JA, Anderson MM, Giacherio DA, Hallock L, Gawryl MS, Lansden C, Tremper KK. The effects of a blood-salvaging device on blood containing a hemoglobin-based oxygen carrier, HBOC-201. J Cardiothorac Vasc Anesth. 1997;11(1):10-12.
Wahr JA, Levy JH, Kindscher J, Tremper KK, Monk T, Jacobs EE, Silverman M, Hughes GS JR. Hemodynamic effects of a bovine hemoglobin based oxygen carrying solution in surgical patients. Anesthesiology. 1996;85(3A):A347. Abstract.
Veterinary Clinical
Alward A, Corriher CA, Barton MH, Sellon DC, Blikslager AT, Jones SL. Red maple (Acer rubrum) leaf toxicosis in horses: a retrospective study of 32 cases. J Vet Intern Med. 2006;20:1197-1201.
Braden TD, Tvedten HW, DeCamp CE, Turner TM, Hughes GS, Rentko VT. Radiographic, biomechanical, and pathologic effects of hemoglobin glutamer-200 in dogs undergoing cemented total hip arthroplasty. Am J Vet Res. 1999;60(11):1337-1340.
*Breen PH, Isserles SA, Tabac E, Roizen MF, Taitelman UZ. Protective effect of stroma-free methemoglobin during cyanide poisoning in dogs. Anesthesiology. 1996;85(3):555-565.
*De Morais HSA, Muir WW, Constable PD. Effects of stroma-free hemoglobin on systolic function in normal dogs. J Vet Intern Med. 1994;8:147(17). Abstract.
DeWitt SF, Bedenice D, Mazan M. Hemolysis and Heinz body formation associated with ingestion of red maple leaves in alpacas. JAVMA. 2004;225(4):578-583.
*Driessen B, Jahr JS, Lurie F, Gunther RA. Addition of hemoglobin-based oxygen carrier Hemoglobin Glutamer-200 (bovine) to 6% hetastarch solution improves restoration of hemodynamic parameters but not oxygen delivery in a canine hypovolemic model. American Society of Anesthesiology. 2001;95:A391. Abstract.
*Driessen B, Jahr JS, Lurie F, Griffey SM, Gunther RA. Effects of haemoglobin-based oxygen carrier Hemoglobin glutamer-200 (bovine) on intestinal perfusion and oxygenation in a canine hypovolaemia model. Br J Anaesth. 2001;86:683-692.
*Driessen B, Jahr JS, Lurie F, Gunther RA. Inadequacy of low-volume resuscitation with hemoglobin-based oxygen carrier hemoglobin glutamer-200 (bovine) in canine hypovolemia. J Vet Pharmacol Ther. 2001;24(1):61-71.
Duggan VE, Holbrook TC, Denchant JE, Blaik MA, Ritchey JW. Diagnosis of aorto-iliac thrombosis in a quarter horse foal using Doppler ultrasound and nuclear scintigraphy. J Vet Intern Med 2004;18:753-756.
Estrin MA, Wehausen CE, Jessen CR, Lee JA. Disseminated intravascular coagulation in cats. J Vet Intern Med. 2006;20:1334-1339.
Fielding CL. A hemoglobin-based oxygen carrier solution for the treatment of parasite-induced anemia in a Barbados sheep. JVECC. 2006;16(1):54-57,
*Fischer TH, Merricks EP, Nichols TC, Raymer RR, Hayes PM, Pearce LB, Bode AP, Manning JE. The co-infusion of rehydrated, lymphilized platelets with HBOC-201 for hemostasis in dilutional thrombocytopenia. Blood. 2001;98(11):538A. Abstract.
Gardner RB, Hart KA, Stokol T, Divers TJ, Flaminio MJBF. Fell poly syndrome in a pony in North America. J Vet Intern Med. 2006;20:198-203.
Giger U, Griot-Wenk M, Rosenzweig M, Macintire D, Resmini C, Canfield D. Purified hemoglobin used as a blood substitute in the treatment of parasite-induced anemia in dogs. J Vet Int Med. 1991;5:140. Abstract.
Gold JR, Divers TJ, deLahunta. Postanesthetic poliomyelopathy in a 7-day-old calf. J Vet Intern Med 2005;19:775-778.
Hohenhaus AE, Rentko VT. Blood transfusions and blood substitutes. In: DiBartola SP, ed. Fluid Therapy in Small Animal Practice. 2nd ed. Philadelphia, Pa: WB Saunders; 2000:451-464.
*Jahr JS, Lurie F, Driessen B, Gunther RA, Golkaryeh MS. Comparing arterial oxygen saturation (SaO2) from a Nellcor Oxygen Saturation Monitor, IL Co-Oximeter and (LEXO2CON) with varying concentrations of Hemoglobin-Based Oxygen Carrier (HBOC) in a dog hemorrhage model. American Society of Anesthesiology. 2001;95:A557. Abstract.
Kelly N, Rentko VT. Comparative cardiovascular response by Oxyglobin® versus packed red blood cells in acute anemia. J Vet Emerg Crit Care. 1998;8(3):252. Abstract.
Lichtenberger, M. Transfusion medicine in exotic pets. Clinical Techniques in Small Animal Practice. 2004;19(2):88-95.
*Lurie F, Jahr JS, Driessen B, Gunther RA, Golkaryeh MS. Mixed venous oxygen saturation (SvO2) measured with an Abbot Oximetric pulmonary artery catheter, and instrumentation laboratory co-Oximeter after resuscitation with varying concentrations of Hemoglobin-Based Oxygen Carrier (HBOC) in a dog hemorrhage model. American Society of Anesthesiology. 2001. Abstract.
*Lurie F, Jahr JS, Driessen B, Tang Z, Louie R. Oxygen saturation measurements in canine blood after hemoglobin glutamer-200 (bovine) (HBOC) infusion: In vitro validation of the Nova Co-Oximeter. Anesthesiology. 2000;93:A407.
*Maxon AD, Giger U, Sweeney CR, Tomasic M, Saik JE, Donawick WJ, Cothran EG. Use of a bovine hemoglobin preparation in the treatment of cyclic ovarian hemorrhage in a miniature horse. J Am Vet Med Assoc. 1993;203(9):1308-1311.
*Moon PF, Bliss SP, Posner LP, Erb HN, Nathanielsz PW. Fetal oxygen content is restored after maternal hemorrhage and fluid replacement with polymerized bovine hemoglobin, but not with hetastarch, in pregnant sheep. Anesth Analg. 2001;93:142-150.
*Orcutt C. Oxyglobin® administration for the treatment of anemia in ferrets. In: Exotic DVM. 2000;2(3):44-46. Abstract.
*Perkins GA, Divers TJ. Polymerized hemoglobin therapy in a foal with neonatal isoerythrolysis. J Vet Emerg Crit Care. 2001;11(2):141-146.
Posner LP, Moon PF, Bliss SP, Gleed RD, Erb HN. Colloid osmotic pressure after hemorrhage and replenishment with Oxyglobin Solution, hetastarch, or whole blood in pregnant sheep. Veterinary Anaesthesia. 2003;30:30-36.
Rentko VT, Cotter SM. Hematopoietic Dysfunction. In: Slatter D, eds. Textbook of Small Animal Surgery. 3rd Ed. Philadelphia , Pa: WB Saunders; 2003;68:1030-1037.
Rentko, VT, Pearce LB, Moon-Massat PF, Hansen BJ, Gawryl MS. Pharmacokinetics of low doses of a hemoglobin-based O2 carrier in dogs with normovolemic anemia. JVIM. 2003;17(3):407(A114) Abstract.
Rentko VT. Practical use of a blood substitute. In: Bonagura JD, ed. Kirk's Current Veterinary Therapy. Philadelphia, Pa: WB Saunders; 2000:424-427.
Rentko VT, Sharpe TA. Red blood cell substitutes. In: Feldman BF, Zinkl JG, Jain NC, eds. Schalm's Veterinary Hematology. 5th ed. Philadelphia, Pa: Lippincott Williams & Wilkins; 2000:874-878.
Rentko VT, Kelly N, Niggemeir A, Giger U. Effects of Oxyglobin® and packed red blood cells (PRBC) on the erythropoietic response to acute anemia. J Vet Int Med. 1998;12(3):227. Abstract.
Rentko, VT. Blood substitutes for emergency use. Proceedings of the 14th ACVIM Forum. San Antonia, Tex: 1996:29-30.
Rentko VT, Wohl J, Murtaugh R, Cotter S, Hohenhaus A, Callan B, Giger U, Hansen B, Jacobson J, Couto G, McLoughlin M, Gawryl MS. A clinical trial of a hemoglobin based oxygen carrying (HBOC) fluid in the treatment of anemia in dogs. J Vet Int Med. 1996;10(3):177. Abstract.
Rentko VT. Red blood cell substitutes. In: Hohenhaus AE, ed. Probl Vet Med. Philadelphia, Pa: JB Lippincott; 1992;4(4):647-651.
Rentko VT, Cotter SM.Transfusion therapy: Red blood cell substitutes and autotransfusion. In: Kirk RW, Bonagura JD, eds. Current Veterinary Therapy. Philadelphia, Pa: WB Saunders; 1992: 104-107.
Rentko VT, Cotter SM. Transfusion therapy in dogs and cats. In: Bojrab MJ, ed. Disease Mechanisms of Small Animal Surgery. Philadelphia, Pa: Lea & Febiger; 1992:44-48.
Rentko VT, Harris JE, Resmini C, Gawryl MS, Rausch CW. Efficacy of an ultra-purified, polymerized hemoglobin based oxygen carrying solution. J Vet Int Med. 1992;6(2):123(58). Abstract.
Soma LR, Uboh CE, Guan F, Luo Y, Moate PJ, Boston RC, Driessen B. The pharmacokinetics of hemoglobin-based oxygen carrier hemoglobin glutamer-200 bovine in the horse. Anesth Analg. 2005;100:570-1575.
Weinkle TK, Center SA, Randolph JF, Warner KL, Barr SC. Evaluation of prognostic factors, survival rates, and treatment protocols for immune-mediated hemolytic anemia in dogs: 151 cases (1993-2002) JAVMA. 2005;226(11):1869-1880
Zambelli AB, Leisewitz AL, Schoeman JP. Oxyglobin and packed red cell transfusions provide similar blood gas, acid base, haemodynamic and subjective benefits in a canine Babesia Rossi model of anaemia. Presented at the 16th ECVIM-CA Congress, 14-16 September 2006, Amsterdam, The Netherlands.
Technical
Alayash AI. Oxygen therapeutics: can we tame haemoglobin? Nature 2004;Vol 3:152-159.
Alayash AI, D'Agnillo F, Buehler PW. First-generation blood substitutes: what have we learned? Biochemical and physiological perspective. Expert Opin. Biol. Ther.2007;7(5):665-675.
Anbari KK, Garino JP, Mackenzie CF. Hemoglobin substitutes. Eur Spine J. 2004;13(Suppl.1): S76-S82.
Bonaventura C, Henkins R, Alayash AI, Crumbliss AL. Allosteric effects on oxidative and nitrosative reactions of cell-free hemoglobins. IUBMB Life Aug - Sep 2007;59(8-9):498-505.
Buehler PW, Alayash AI. Toxicities of hemoglobin solution: in search of in-vitro and in-vivo model systems. Transfusion. 2004;44:1516-1530.
Callan MB, Rentko VT. Clinical application of a hemoglobin-based oxygen-carrying solution. Vet Clin Small Anim. 2003;33:1277-1293.
Day TK. Current development ad use of hemoglobin-based oxygen-carrying (HBOC) solutions. J Vet Emerg Crit Care. 2003;13(2):77-93.
*Douglas E. Blood Substitute Found Safe, Effective in Anemic Patients. Anesthesiology News. 7/23/03. Based on a presentation (Abstract A-243) at the 2002 annual meeting of the American Society of Anesthesiologists, a presentation (Abstract S-330) at the 2002 annual meeting of the International Anesthesia Research Society and interviews with Jonathan S. Jahr, MD, Nancy A. Nussmeier, MD, and Paul G. Barash, MD.
Driessen B, Brainard B. Fluid therapy for the traumatized patient. JVECC 2006;16(4):276-299.
Estep TN. Expectations and implications of blood sparing with hemoglobin based oxygen carriers. Artif Cells Blood Substit Immobil Biotechnol. 2007;35(1):93-105.
Estep T, Bucci E, Farmer M, Greenburg G, Harrington J, Kim HW, Klein H, Mitchell P, Nemo G, Olsen K, Palmer A, Valeri RC, Winslow R. Basic science focus on blood substitutes: a summary of the NHLBI Division of Blood Diseases and Resources Working Group Workshop, March 1, 2006. Transfusion 2008;48:776-782.
Fleming P, Ferguson E, Townsend E, Lowe KC. Perceptions in transfusion medicine: a pilot field study on risk and ethics for blood and blood substitutes. Artif Cells Blood Substit Immobil Biotechnol. 2007;35:149-156.
Hall RI. The utility of hemoglobin based oxygen carriers (HBOC) – can animal studies help? Can J Anaesth. 2005;52(9):895-898.
Henkel-Hanke T, Olek M. Artificial oxygen carriers: a current review. AANA Journal. June 2007;Vol 75, No.3:205-211.
Hohenhaus AE. Editorial: Oxyglobin: A transfusion solution. J Vet Intern Med. 2002;16:394-395.
Jacobs EE, Gawryl MS, Pearce LB. Enhancing oxygenation - alternatives to packed red blood cells. Interface. 1999;10(3):1-10.
Jahr JS, Walker V, Manoochehri K. Blood substitutes as pharmacotherapies in clinical practice. Curr Opin Anaesthesiol. 2007;20:325-330.
Kim HW, Greenburg AG. Artificial oxygen carriers as red blood cell substitutes: A selected review and current status. Artificial Organs 2004;28(9):813-828.
Kim HW, Greenburg AG. Toward 21st century blood component replacement therapeutics: artificial oxygen carriers, platelet substitutes, recombinant clotting factors, and other. Artif Cells Blood Substit Immobil Biotechnol. 2006;34:537-550.
*Levy J. The use of haemoglobin glutamer-250 (HBOC-201) as an oxygen bridge in patients with acute anaemia associated with surgical blood loss. Expert Opin Biol Ther. 2003;3(3):509-517.
Light WR, Jacobs EE, Rentko VT, Gawryl MS, Hughes GS. Use of HBOC-201 as an oxygen therapeutic in the preclinical and clinical settings. In: Rudolph AS, Rabinovici R, Feuerstein GZ, eds. Red Blood Cell Substitutes: Basic Principles and Clinical Applications. Marcel Dekker Inc; 1998:19:421-36.
Mackenzie CF, Bucci C. Artificial oxygen carriers for trauma: myth or reality? Hospital Medicine, October 2004; Vol 65, No 10:582-588.
Mosa MM, Cheng DCH. Oxygen therapeutics (blood substitutes) in cardiac surgery. Current Opinion in Anaesthesiology. 2003;16(1):21-26.
*Muir WW, Wellman ML. Hemoglobin solutions and tissue oxygenation. J Vet Intern Med. 2003;17:127-135.
*Ness PM, Cushing MM. Oxygen Therapeutics Pursuit of an Alternative to the Donor Red Blood Cell Arch Pathol Lab Med. 2007;131:734-741.
Rentko VT, Pearce LB, Moon-Massat PF, Gawryl MS. Hemopure [HBOC-201, Hemoglobin Glutamer-250 (Bovine)]: Preclinical Studies. Blood Substitutes. In.: Winslow RM, ed. London, UK: Elsevier Inc.; 2006:424-436.
Schutte AE. Ethical considerations concerning South Africa's approval of a blood substitute. Ethics & Medicine. 2002;18(2):55-62.
Spahn DR, Kocian R. Artificial O2 carriers: status in 2005. Current Pharmaceutical Design. 2005;11:4099-4114.
Stollings JL, Oyen LJ. Oxygen Therapeutics: Oxygen Delivery without Blood. Pharmacotherapy. 2006;26(10):1453-1464.
Tsai AG, Cabrales P. Can the effects of vasoactivity of molecular hemoglobin-based plasma expanders be ignored? Crit Care Med. 2006;34(5):1566-1567.
Waschke KF, Frietsch TH, Quintel M, Lenz C, Rebel A. Hemoglobin solutions. Blood Banking and Transfusion Medicine. 1997; 5(111):259-263.
Winslow RM. Current status of oxygen carriers (‘blood substitutes'):2006. Vox Sanguinis. 2006;91:102-110.
*Cabrales P, Tsai AG, Intaglietta M. Increased tissue PO2 and decreased O2 delivery and consumption after 80% exchange transfusion with polymerized hemoglobin. Am J Physiol Heart Circ Physiol. 2004;H2825-H2833.
Dimino ML, Palmer AF. Hemoglobin-based O2 carrier O2 affinity and capillary inlet pO2 are important factors that influence O2 transport in a capillary. Biotechnol. Prog. 2007;23:921-931.
Dunn JF, Nwaigwe C, Roche M, Zhu H, Grinberg OY, Pearce BP, Gawryl MS. Mitigation of acute hypoxia in brain by infusion of the acellular hemoglobin HBOC-201: a bold MR imaging study. ISOTT Proceedings, 1999:54. Abstract.
Freitag M, Standl TG, Gottschalk A, Burmeister MA, Rempf C, Horn EP, Strate T, Schulte am Esch J. Enhanced central organ oxygenation after application of bovine cell-free hemoglobin HBOC-201. Can J Anesth 2005; 52(9): 904-914
Gottschalk, A.; Raabe, A.; Hommel, M.; Rempf, C.; Freitag, M.; Standl, T. Influence of the Hemoglobin Solution HBOC-201 on Tissue Oxygenation in the Rat R1H-Tumor. Artificial Cells, Blood Substitutes, and Biotechnology. 2005; 33; 379-389
Henderson CL, Anderson MD, Sorrells DL, Wilson BJ, Dick EJ, DiGeronimo RJ. The use of a hemoglobin-based oxygen-carrying solution (HBOC-201) for extracorporeal membrane oxygenation in a porcine model with acute respiratory distress syndrome. Pediatr Crit Care Med. 2004;5(4):384-390.
*Horn EP, Standl T, Wilhelm S, Jacobs EE, Freitag U, Freitag M, Schulte am Esch J. Bovine hemoglobin HBOC-201 causes a reduction of the oxygen partial pressure in poststenotic skeletal muscle. Anaesthesist. 1998;47(2):116-123. Abstract (English). Article in German.
*Horn EP, Standl T, Wilhelm S, Jacobs EE, Freitag U, Freitag M, Schulte am Esch J. Bovine hemoglobin increases skeletal muscle oxygenation during 95% artificial arterial stenosis. Surgery. 1997;121(4):411-418.
Jacobs EE, Gawryl MS. Tissue oxygen effects of HBOC-201 versus red blood cells. Progress in Applied Microcirculation: Microcirculatory Effects of Hemoglobin Solutions (Book). 2004;Volume 25,pp 16-26, Edited by K. Messmer, K.E. Burhop, J. Hunter. Basel, Karger.
Loke KR, Forfia PR, Recchia FA, Xu X, Osorio JC, Ochoa M, Gawryl MS, Hintze TH. Bovine polymerized hemoglobin increases cardiac oxygen consumption and alters myocardial substrate metabolism in conscious dogs: role of nitric oxide. J Cardiovasc Pharmacol. 2000;35:84-92.
Manley GT, Hemphill C, Morabito D, Erickson V, Holcroft JJ, Derugin N, Knudson MM. Small-volume resuscitation with the hemoglobin substitute HBOC-201: Effect on brain tissue oxygenation. Oxygen Transport to Tissue XXIV. Eds. Dunn and Schwartz, KluwerAcademia / Plenum Publishers. 2003;29:311-317.
Page TC, Light WR, Hellums JD. Experimental and mathematical simulation of oxygen transport by hemoglobin-based blood substitutes. In Tsuchida E, ed. Blood Substitutes – Present and Future Perspectives. New York: Elsevier 1998;135-145.
Page TC, Light WR, Hellums JD. Prediction of microcirculatory oxygen transport by erythrocyte/hemoglobin solution mixtures. Microvasc Res. 1998;56(2):113-126.
Page TC, Light WR, McKay CB, Hellums JD. Oxygen transport by erythrocyte/hemoglobin solution mixtures in an in vitro capillary as a model of hemoglobin-based oxygen carrier performance. Microvasc Res. 1998;55(1):54-64.
Page TC, McKay CB, Light WR, III, Hellums JD. Experimental simulation of oxygen transport in microvessels In: Winslow RM, Vandegriff KD, Intaglietta M, eds. Blood Substitutes: New Challenges. Boston, Mass: Birkhauser; 1996;9:132-45.
Page TC, McKay CB, Light WR, Hellums JD. Experimental and theoretical simulation of oxygen transport with erythrocytes and extracellular hemoglobin-based materials. Artif Cells Blood Substit Immobil Biotechnol. 1996;24(4):399. Abstract.
Pawson, P., Gibson, I. F., Dowell, F. J. The effect of the polymerized bovine haemoglobin solution, Hb-200, on endothelial function in isolated arterial rings from -rats. J. vet. Pharmacol. Therap. 30, 556-563.
Raabe A, Gottschalk A, Hommel M, Dubben H, Strandl T. No effect if the hemoglobin solution HBOC-201 on the response of the rat R1H tumor to fractionated irradiation. Strahlenther Onkol 2005; 11: 730-737
Rempf C, Ritter A, Schrepfer S, Freitag M, Standl T, Gottschalk A. Failed induction of Heme Oxygenase 1 in endothelial cells exposed to the hemoglobin based oxygen carrier Oxyglobin®. Artif Cells, Blood Subs Biotechnol. 2008;36(1):34 - 44.
Robinson MF, Dupuis NP, Kusumoto T, Liu F, Menon K, Teicher BA. Increased tumor oxygenation and radiation sensitivity in two rat tumors by a hemoglobin-based, oxygen-carrying preparation. Artif Cells Blood Substit Immobil Biotechnol. 1995;23(3):431-438.
*Standl T, Freitag M, Burmeister MA, Horn EP, Wilhelm S, Schulte am Esche J. Hemoglobin-based oxygen carrier HBOC-201 provides higher and faster increase in oxygen tension in skeletal muscle of anemic dogs than do stored blood cells. J Vasc Surg. 2003;37:859-65.
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